Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage

Bispebjerg Hospital

Status and phase: Completed; Phase 4

Conditions: Keratosis, Actinic

Treatments: Drug: No curettage; Drug: Curettage

Study type: Interventional

Funder types: Other

Identifiers

NCT03697590

PDT with and without curettage

Details and patient eligibility

About

Guidelines for photodynamic therapy (PDT) of actinic keratosis recommend pretreatment with curettage. The impact of curettage on the treatment effect is, however, not known. The present study aimed to evaluate whether daylight-PDT without curettage would reduce treatment effect compared to daylight-PDT with curettage.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Multiple actinic keratosis on the forehead or scalp

Exclusion criteria

• Known allergy to methyl aminolevulinate
• Porphyria
• Pregnancy
• Lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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25 participants in 2 patient groups

PDT with no curettage

Experimental group

Treatment:

Drug: No curettage

Standard PDT

Active Comparator group

Treatment:

Drug: Curettage