Physical Activity and Cognitive Behavioural Therapy in Panic Disorder and Agoraphobia
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Treatments
Details and patient eligibility
About
Physical activity (treadmill) prior to in-vivo exposure supports the effect of cognitive behavioural therapy in patients with panic disorder and agoraphobia.
Full description
Patients receive a 12-session manualized cognitive behavioural therapy, implemented over 7 weeks and followed by two booster sessions. Five sessions consist of in-vivo exposures. Prior to these sessions patients undergo a training of physical activity. Half of the patients complete training on a treadmill at 70% of their maximal oxygen uptake while the other half complete training at 30%.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Subject familiarized with experimental procedure and had given written informed consent
- Diagnosis of panic disorder with agoraphobia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
- Score >= 18 in Hamilton Rating Scale for Anxiety
- Score >= 4 in Clinical Global Index
- Reachability of patient for treatment and follow-up
Exclusion criteria
- DSM-IV Axis I diagnoses of any psychotic disorder, bipolar disorder, current alcohol or drug dependence and Axis II borderline personality disorder
- Change in pharmacological treatment in the last 4 weeks
- Acute suicidality
- Medical contraindications for mild to moderate exercise training or exposure
Trial design
Primary purpose
Allocation
Interventional model
Masking
78 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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