Physical Activity for a Long and Healthy Life (FINE)

University of Copenhagen

Status: Completed

Conditions: Overweight; Insulin Resistance; Diabetes Mellitus, Type 2

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01430143

FourINonE

Details and patient eligibility

About

The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.

Enrollment: 64 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy according to interview
• Caucasian
• Sedentary, Vo2max < 45 ml/kg/min
• BMI 25-30 kg/m2
• Fat percentage 25% <
• Weight stable (+/- 2 kg within past 6 months)

Exclusion criteria

• First degree relatives with type 2 diabetes
• Hemoglobin concentration < 8 mmol/l
• Fasting plasma glucose 6.1 mmol/l <
• Blood pressure 140/90 mmHg <
• Regular intake of medicine

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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64 participants in 3 patient groups

600 kcal/day

Experimental group

Description:

Exercise combusting 600 kcal/day, 7 days/week for 12 weeks.

Treatment:

Behavioral: Exercise

300 kcal/day

Experimental group

Description:

Exercise combusting 300 kcal/day, 7 days/week for 12 weeks.

Treatment:

Behavioral: Exercise

Sedentary

No Intervention group

Description:

Continued sedentary living.