Physical Activity Stress and Sleep in Adolescents (APADOSLEEP)

Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose

Status: Unknown

Conditions: Adolescent Problem Behavior

Treatments: Behavioral: Group/Cohort 2: PAP

Study type: Interventional

Funder types: Other

Identifiers

NCT04187885

University Tunis El Manar

Details and patient eligibility

About

Adolescence is characterized by major transitions in sleep and circadian rhythm. This rapid pivotal period increases the risks of sleep debt and poor sleep quality, leading to pronounced diurnal fatigue and drowsiness. On the other hand, academic stress has been also associated with increased sleep disturbances.

Both academic stress and poor sleep in adolescents has been linked to increased sleepiness rate, reduced alertness, lower academic performances and the impairment of the control of energy balance through hyperphagia.

Despite the importance of sleep in holistic development, physical (i.e. recovery, metabolism, muscle growth, weight control), cognitive (i.e. learning, memory, decision-making, Vigilance). Few studies have been designed to improve this behavior among college adolescents, especially in times of academic stress.

Physical activity has been suggested as a non-pharmacological alternative treatment for sleep disorders . Generally, it is well established that the duration and quality of sleep were improved by regular physical activity among adolescents and far better, it was suggested that the exercise-mediated effect on sleep could be even observed in the short term. Moreover, it was suggested that aerobic exercise has positive effects on psychological stress and well-being of adolescents .

Therefore, APADOSLEEP trial, was designed to examine the effect of physical activity program on sleep during and outside periods of academic stress.

Full description

Counterbalanced, cross-over, pre-post trial where each subject acts as his own control.

Four sessions will be performed for each adolescent. Each session will be conducted over 5 days (from Monday to Friday):

Adolescents will take part randomly in four sessions. Physical activity program will be identical between sessions and groups. 60 minn of moderate to vigorous leisure activities and exercises will be proposed each day. Heart rate monitor will be used to control intensity of exercise during the physical activity program.

• Control session (CTL) outside academic stress period (represented by exams) and without the physical activity program.
• A session outside academic stress period, with the physical activity program (PAP).
• A session during an academic stress period without the physical activity program (AS).
• A session during an academic stress period with the physical activity program (ASPAP).

At each session:

• Continuous sleep assessments (duration and quality) by accelerometry
• Continuous physical activity and sedentary behaviour assessments by accelerometry
• one evaluation of melatonin peak from salivary specimens
• one evaluation of cortisol peak from salivary specimens
• An evaluation of the ad libitum food intake of the 5th day will be carried out by the weighing method.
• one assessment of cognitive performance
• An evaluation of subjective appetite sensations (hunger, fullness, desire to eat) of the 5th day
• An evaluation of subjective diurnal sleepiness (Karolinska) of the 5th day

Enrollment: 56 estimated patients

Sex: Male

Ages: 14 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• college adolescent Tanner stages 3-5

Exclusion criteria

• Disorders and / or pathology of sleep
• Medical or surgical history not compatible with the study, any other chronic illness or injury that may interfere with the subject's abilities
• Take medication that may interfere with the results of the study (corticosteroids ...) or sleeping pills
• Surgical intervention in the previous 3 months
• Regular consumption of tobacco, cannabis or alcohol
• Special diet

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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56 participants in 4 patient groups

Group/Cohort 1 : CTL

Active Comparator group

Description:

Label : control Type : comparator Description: Outside academic stress period (represented by exams), without the physical activity program (no Intervention).

Treatment:

Behavioral: Group/Cohort 2: PAP

Group/Cohort 2: PAP

Experimental group

Description:

Label : physical activity program without stress Type : experimental Description: outside academic stress period (exams), with the physical activity program:60 min of mederate to vigorous leisure activities and exercises will be proposed from Monday to Thursday.

Treatment:

Behavioral: Group/Cohort 2: PAP

Group/Cohort 3: AS

Experimental group

Description:

Label : academic stress Type : experimental Description: during academic stress period (exams), without the physical activity program (no Intervention)

Treatment:

Behavioral: Group/Cohort 2: PAP

Group/Cohort 4: ASPAP

Experimental group

Description:

Label : academic stress and physical activity program Type : experimental Description: during academic stress period (exams), with the physical activity program: 60 min of mederate to vigorous leisure activities and exercises will be proposed from Monday to Thursday.

Treatment:

Behavioral: Group/Cohort 2: PAP