Physical Exercise as a Targeted Therapy in Patients With Chronic Rheumatic Muscle Inflammation

Karolinska Institute

Status: Unknown

Conditions: Myositis

Treatments: Other: Physical Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01184625

Exercise

Details and patient eligibility

About

The objectives of this study are to test if hypoxia in muscle tissue is an important factor contributing to clinical symptoms in chronic rheumatic muscle inflammation and to evaluate if a 12 week endurance exercise program will improve muscle tissue hypoxia and disability in patients with chronic rheumatic muscle inflammation.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with chronic, stable polymyositis or dermatomyositis with diagnosis of definite or probable polymyositis or dermatomyositis (Bohan and Peter 1975)
• Age 18-80 years
• Duration since diagnosis > 6 months
• Exercising < once a week,
• Stable disease activity and medication for at least one month.

Ten healthy controls matched for age, gender and physical exercise level will be included.

Exclusion criteria

• Severe pulmonary fibrosis
• Heart or lung conditions that contraindicate vigorous exercise
• Severe osteoporosis
• Not being able to perform the exercise program.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Exercise

Experimental group

Treatment:

Other: Physical Exercise

No intervention

No Intervention group

Description:

12 weeks of stable physical exercise level.