Physical Exercise, Endothelial Function and Progenitor Endothelial Cells in Systemic Lupus Erythematosus Patients

Federal University of São Paulo

Status

Unknown

Conditions

Systemic Lupus Erythematosus

Treatments

Behavioral: Supervised physical exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01712529

09295-5

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of supervised physical exercise on endothelial function and number of endothelial progenitor cells (EPCs) in patients with systemic lupus erythematosus, as well as evaluate the effect of supervised physical exercise on endothelium derived growth factor (VEGF) levels, disease activity, quality of life, fatigue, perceived exertion and cardiopulmonary exercise test variables.

Full description

Several studies have shown that cardiovascular morbimortality is more frequent and early in SLE patients than in the general population and cardiovascular disease is an important cause of morbidity and mortality in systemic lupus erythematosus patients. Disturbances in endothelial function are implicated in its pathogenesis. Endothelial function also depends on endothelial progenitor cells (EPCs) that enhance angiogenesis, promote vascular repair and have potential as a marker of cardiovascular disease. Systemic lupus erythematosus patients have endothelial dysfunction and fewer EPCs. There are studies showing improvement of endothelial function and EPCs after physical exercise program in individuals with heart failure, diabetes and coronary arterial disease, but there isn't studies evaluating endothelial function and EPCs after.

Enrollment

38 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

female systemic lupus erythematosus patients
18 to 45 years of age
Fulfilled at least four criteria classification for lupus (ACR criteria, 1997) - Signed the consent form approved by the ethics committee of the institution

Exclusion criteria

Hemoglobin < 10 mg/dL
Neuropsychiatric, pulmonary, articular or vascular damage that would prevent the practice of exercise
Coronary disease or heart failure, functional class ≥ II
Pulmonary hypertension
Uncontrolled hypertension
Creatinine ≥ 1.4 mg/dL
Body mass index (BMI) ≥ 35 kg/m2
Diabetes mellitus
Uncontrolled hypothyroidism
Smoking in the last 12 months
Pregnancy
Menopause
Use of statins in the last three months
Practice of physical exercise in past three months
Overlap with other autoimmune rheumatic diseases, except antiphospholipid syndrome.