Physical Exercise Versus Rosiglitazone in CAD and Prediabetes

University of Leipzig

Status and phase: Completed; Phase 4

Conditions: Impaired Glucose Tolerance

Treatments: Drug: rosiglitazone; Other: control; Behavioral: physical exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00675740

Leipzig 03

Details and patient eligibility

About

The aim of this study is to prospectively assess the relative benefits of either treatment with rosiglitazone or physical exercise on endothelial function in patients with impaired fasting glucose or impaired glucose tolerance and coronary artery disease (CAD).

Enrollment: 45 patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• impaired fasting glucose or impaired glucose tolerance
• angiographic evidence of coronary artery disease

Exclusion criteria

• diabetes mellitus type I or II
• preexisting antidiabetic medication
• unstable angina
• indication for coronary bypass surgery
• significant left main disease
• myocardial infarction within preceding 3 months
• ejection fraction < 40%
• significant heart valve disease
• severe metabolic disorders
• severe disorders in lipoprotein metabolism
• thyroid disorders
• alcohol or drug abuse
• pregnancy
• participation in another trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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45 participants in 3 patient groups

1

Experimental group

Treatment:

Drug: rosiglitazone

2

Active Comparator group

Description:

physical exercise

Treatment:

Behavioral: physical exercise

3

No Intervention group

Description:

control

Treatment:

Other: control