Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2 (PRIME-Knee)

Duke University

Status: Completed

Conditions: Aging; Resilience

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04235309

Pro00103483

4UH3AG056925-03 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).

Full description

In general, a person's specific resilience (ability to bounce back from a stressor) is thought to be dependent upon that person's specific biological and genetic makeup. However, these specific elements remain poorly understood. The purpose of this study is to identify important predictors and characteristics of resilience in response to a total knee replacement by examining baseline resilience (prior to surgery) and post-surgical resilience at multiple time points, allowing us to track resilience outcomes over time.

Enrollment: 297 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 60 years of age or older
• Ability to speak English
• Planned elective knee replacement orthopedic surgery lasting 2 or more hours and requiring overnight observation or inpatient stay
• Community dwelling

Exclusion criteria

• Unable to ambulate independently, with or without assistive device
• Known dementia or screening 3MS score <=77
• Inmate of a correctional facility (i.e. prisoners)
• Active non-skin cancer or medical treatment for non-skin cancer with 12 months (chemotherapy, radiation, immunotherapy, hormonal therapy)
• Vision or hearing impairment that, after best accommodation, prevents reliable cognitive assessment (visual/hearing) and/or precludes telephone interviews (hearing)

Trial design

297 participants in 1 patient group

Total Knee Replacement Cohort

Description:

Any patients who are scheduled to undergo a total knee replacement.