Physiological and Appetitive Effects of CBD Supplementation

Loughborough University

Status: Enrolling

Conditions: Appetitive Behavior; Adverse Effect; Metabolic Health

Treatments: Dietary Supplement: Placebo supplementation; Dietary Supplement: Cannabidiol (CBD) supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT05774574

11031 (Registry Identifier)

Details and patient eligibility

About

CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether four weeks of supplementation with 60 mg/day CBD affects energy intake at a single meal, and or fasting blood-based markers of appetite regulation and metabolic health. Healthy, adult volunteers will be assigned to placebo or CBD supplementation, in a randomized controlled trial, comparing changes in outcomes across the supplementation period between groups.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

• No history of any substance abuse
• Have used tobacco regularly (>2x in a week) within the past 6 months
• Are suffering from any condition that may affect study outcomes
• Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers)
• Have given a standard blood donation within 30 days of screening
• Are currently pregnant or lactating
• Are allergic/intolerant to any ingredients in food items we provide during the study (relevant allergens: oats, milk)

Inclusion Criteria:

• Males and females, aged 18-50, who do not meet the exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

CBD

Experimental group

Description:

1 mL hemp oil containing 60 mg/mL CBD, daily.

Treatment:

Dietary Supplement: Cannabidiol (CBD) supplementation

Placebo

Placebo Comparator group

Description:

1 mL hemp oil containing 0 mg/mL CBD, daily.

Treatment:

Dietary Supplement: Placebo supplementation