Physiological and Biochemical Responses to Blood Flow Restriction Training

Afyonkarahisar Health Sciences University

Status: Not yet enrolling

Conditions: Trained Athletes; Healthy Individuals

Treatments: Other: Blood Flow Restriction Training

Study type: Observational

Funder types: Other

Identifiers

NCT07340385

2025/9

Details and patient eligibility

About

This study is designed to examine the short-term and long-term effects of blood flow restriction exercise training on physiological and biochemical markers in individuals who are new to strength training and in experienced athletes training at different load levels. This exercise method involves placing a special inflatable cuff around the upper part of the thigh. The cuff partially limits blood flow to the area, which helps the muscles work more effectively during exercise. The cuff will be applied only to the individual's dominant leg (the leg you use more often in daily activities), but all exercises will be performed using both legs. The exercise program will last for a total of six weeks and will be carried out twice per week. The pressure applied by the cuff will be individually adjusted based on each participant's physical characteristics to ensure safety and comfort. The study will include a total of 30 healthy participants aged between 18 and 40 years. Participants will be divided into two groups: individuals who have recently started strength training and experienced athletes with different levels of training experience.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Voluntary participation of healthy adults (both female and male)
• Age between 18 and 40 years
• No history of orthopedic pathology or current symptoms affecting the lower extremities
• For individuals with prior training experience: engagement in strength training at least two days per week for the past year across different sports disciplines
• For individuals new to strength training: no regular participation in strength training within the past six months

Exclusion criteria

• History of hypertension, cardiovascular diseases, peripheral vascular diseases, deep vein thrombosis, neurological disorders, obesity, or a diagnosis of diabetes
• Current or previous diagnosis of cancer
• Pregnancy
• Individuals who do not consent to participate in the study

Trial design

30 participants in 2 patient groups

Novice Training Group

Description:

This group consists of healthy individuals who are new to strength training. Participants in this group will perform low-intensity resistance exercises with blood flow restriction applied to the proximal thigh using an inflatable cuff.

Treatment:

Other: Blood Flow Restriction Training

Experienced Athletes Group

Description:

This group includes healthy experienced athletes from different sports disciplines and training load levels. Participants will perform the same low-intensity blood flow restriction exercise protocol applied to the proximal thigh using an inflatable cuff.

Treatment:

Other: Blood Flow Restriction Training