Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease

University Hospital Basel

Status: Unknown

Conditions: Barlow Disease (BD); Mitral Insufficiency

Treatments: Diagnostic Test: Magnetic resonance imaging (MRI)

Study type: Observational

Funder types: Other

Identifiers

NCT04418960

2018-02240 ch20Grapow;

Details and patient eligibility

About

Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• identified Barlow disease suffering from significant mitral insufficiency with indication to surgery

Exclusion criteria

• Active endocarditis or any other etiology of mitral insufficiency else than Barlow disease
• Inability to perform a cardiac MRI (e.g., metallic implants, claustrophobia)
• Pregnancy
• Inability to give consent