Physiological Effects of APRVplus and TCAV in ARDS

Sichuan University

Status

Completed

Conditions

ARDS (Acute Respiratory Distress Syndrome)

Treatments

Procedure: TCAV

Procedure: APRVplus

Study type

Interventional

Funder types

Other

Identifiers

NCT06748807

2023 approved No.193

Details and patient eligibility

About

In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed. This study aims to compare the physiological effects of two types of APRV ventilation strategy, Early Pathophysiology-driven APRV (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV), through randomized crossover trials, providing evidence for clinical application and further research on APRV.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

intubated and mechanically ventilated patients
meet the 2023 global new definition of ARDS

Exclusion criteria

Pregnancy
The expected duration of mechanical ventilation was less than 48 hours
Intracranial hypertension (suspected or confirmed)
Neuromuscular disorders that are known to prolong the need for mechanical ventilation
Known or suspected chronic obstructive pulmonary disease(COPD)
Terminal stage of disease
Pneumothorax (drained or not)at enrollment
Treatment with extracorporeal support (ECMO) at enrollment
There was a lack of commitment to life support