Physiological Effects of Creatine Supplementation in Active Males (NB4)

Texas A&M University

Status: Completed

Conditions: Dietary Supplementation

Treatments: Dietary Supplement: Creatine nitrate; Dietary Supplement: Placebo; Dietary Supplement: Creatine monohydrate

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03003988

IRB2014-0503FX

Details and patient eligibility

About

This study was designed to examine how different forms of creatine impact active males.

Full description

This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.

Enrollment: 48 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• participants are apparently healthy and recreationally active males between the ages of 18 and 40;
• participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;

Exclusion criteria

• participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
• participants are currently using prescription medications;
• participants have a history of smoking;
• participants drink excessively (i.e., 12 drinks per week or more);
• participants have a recent history of creatine supplementation within six weeks of the start of supplementation;

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 3 patient groups, including a placebo group

Creatine monohydrate

Experimental group

Description:

Creatine monohydrate (6.0 g.) + dextrose (0.5 g.)

Treatment:

Dietary Supplement: Creatine monohydrate

Creatine nitrate

Active Comparator group

Description:

Creatine nitrate (5.0 g. creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio).

Treatment:

Dietary Supplement: Creatine nitrate

Placebo

Placebo Comparator group

Description:

6.5 g. dextrose

Treatment:

Dietary Supplement: Placebo