Physiological Effects of HFNC During Exercise in Patients With Fibrosing Interstitial Lung Diseases (HighFlowMusc)

ADIR Association

Status: Enrolling

Conditions: Pulmonary Rehabilitation; Interstitial Lung Disease

Treatments: Device: high flow nasal canulae; Device: Ventury mask

Study type: Interventional

Funder types: Other

Identifiers

NCT05372926

HighFlowMusc

Details and patient eligibility

About

in this study, the investigators aim to describe the effects of highflow nasal canulae oxygen therapy (HFNC) on respiratory muscle function during exercise in patients with fibrosing interstitial lung diseases (ILD) during an endurance test

Enrollment: 16 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cared for as part of a respiratory rehabilitation program (ADIR association)
• Presenting diffuse fibrosing interstitial pneumonitis, documented by CT scan data and whatever its etiology
• Presenting severe hypoxemia in ambient air (SpO2<90%) during an exercise test (6-minute walk test or functional exercise test)

Exclusion criteria

• Patient with a contraindication to carrying out a respiratory rehabilitation program
• Patient having presented an exacerbation of PID, pneumothorax or pneumomediastinum in the 3 months preceding potential inclusion
• Tracheostomized patient
• Patient with a contraindication to the placement of a nasogastric tube
• Pregnant or breastfeeding women or women of childbearing age without effective means of contraception (a pregnancy test will be carried out)
• Protected adult patient (guardianship or curatorship)
• Patient deprived of liberty by court or administrative decision
• Refusal of patient participation or consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

Venturi mask

Experimental group

Description:

Patients will be placed under oxygen therapy with Venturi mask at a constant flow of 15L/min and a set FiO2 of 50%. The real FiO2 will be mesured in the mask at rest.

Treatment:

Device: Ventury mask

High flow nasal canulae

Experimental group

Description:

Patients will be placed under high flow nasal canulae oxygen therapy with a constant flow of 50L/min and the real FiO2 provided by Venturi mask.

Treatment:

Device: high flow nasal canulae