Physiological Effects of High-flow Nasal Cannula During Exercise

Pontificia Universidad Catolica de Chile

Status: Completed

Conditions: Healthy Volunteers

Treatments: Device: High-flow Nasal Cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT05550935

220510003

Details and patient eligibility

About

The high-flow nasal cannula (HFNC) has increased its evidence in patients during pulmonary rehabilitation. These studies hypothesize that the physiological effects of HFNC (positive expiratory pressure, anatomical dead space lavage, thermo-humidification) lead to an increase in exercise time. This is believed to be due to improvements that the device can generate in the respiratory system and muscles. However, the physiological effects of HFNC on respiratory effort and distribution of pulmonary ventilation during exercise are unknown. The aim of this study is to determine the acute effect of high flow nasal cannula on the distribution of pulmonary ventilation and respiratory effort during physical exercise in healthy subjects.

Full description

A randomized, cross-over clinical trial in which either HFNC or Sham may be used as an adjunct on a cycle ergometer in random order will be performed to compare the respiratory effort and distribution of pulmonary ventilation continuously. Measurements will be taken in a warm-up, exercise, and recovery phase for both groups.

Enrollment: 14 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults volunteers
• Physically inactive (according to World Health Organization criteria).

Exclusion criteria

• Refusal to participate
• Smokers
• History of acute cardiorespiratory or musculoskeletal disease during the last year (including COVID-19 when hospitalization or supplemental oxygen was required without any other disease)
• Any neuromuscular or cardiovascular or condition that limits test performance.
• Contraindication for esophageal catheter installation (recent epistaxis, severe coagulopathy, among other).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

HFNC Group

Experimental group

Description:

Healthy subject will perform one Constant Work-Rate Exercise Test at respiratory compensation point as determined by a cardiopulmonary exercise test with High Flow Nasal at 60L/min (without additional oxygen)

Treatment:

Device: High-flow Nasal Cannula

Control Group

Sham Comparator group

Description:

Healthy subject will perform one Constant Work-Rate Exercise Test at respiratory compensation point as determined by a cardiopulmonary exercise test with High Flow Nasal at 2L/min (without additional oxygen)

Treatment:

Device: High-flow Nasal Cannula