Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS

XiaoJing Zou,MD

Status: Enrolling

Conditions: ARDS: Acute Respiratory Distress Syndrome

Treatments: Device: EIT-guided Phigh settings during APRV

Study type: Interventional

Funder types: Other

Identifiers

NCT06696638

APRVPhigh2024

Details and patient eligibility

About

This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.

Enrollment: 26 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with ARDS according to the 2023 global new definition of ARDS.
• Age ≥ 18 years.

Exclusion criteria

• Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
• Pulmonary interstitial disease.
• Uncorrected shock of various types.
• Intracranial hypertension.
• Pregnant and postpartum women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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26 participants in 2 patient groups

Intervention group

Experimental group

Description:

EIT-guided Phigh settings during APRV

Treatment:

Device: EIT-guided Phigh settings during APRV

Control group

No Intervention group

Description:

Pplat-guided Phigh settings during APRV