Physiological Response to 5 Days Fasting

Charité University Medicine Berlin

Status: Completed

Conditions: Healthy

Treatments: Other: Buchinger fasting

Study type: Interventional

Funder types: Other

Identifiers

NCT04452916

LEANER

Details and patient eligibility

About

To investigate energy metabolism, anthropometry, blood pressure, gut microbiome, serum metabolome, glucose variability and neural mechanisms of food choice and mood before and after 5 days of fasting as well as their persistence in healthy men and women.

Enrollment: 55 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women
• 20-50 years
• Body mass index 20-30 kg/m2

Exclusion criteria

• Clinically relevant heart, lung, liver, and kidney diseases
• Any prescribed medication (except for oral contraceptives)
• Current or chronic infection
• Intake of antibiotics within 6 months before study entry
• Fasting week within 6 months before study entry
• Habitual use of dietary supplements
• Food intolerances
• Pregnancy, lactation
• Vegan diet
• Smokers
• In addition for fMRI: sensorineural hearing loss, tinnitus, metal implants, electric devices

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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55 participants in 2 patient groups, including a placebo group

Fasting

Active Comparator group

Description:

Starts immediately with 5 days of Buchinger fasting

Treatment:

Other: Buchinger fasting

Waiting list control

Placebo Comparator group

Description:

Starts with 5 days of Buchinger fasting after a waiting period of 12 weeks

Treatment:

Other: Buchinger fasting