Physiological Response to Salbutamol and Exercise

University of Copenhagen

Status: Unknown

Conditions: Healthy

Treatments: Drug: salbutamol; Other: exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03902106

SALB

Details and patient eligibility

About

The scope of the study is to investigate the physiological response to salbutamol and exercise. A particular focus is on the metabolic response and amine metabolism.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• VO2max of >55 ml/min/kg for men and >50 ml/min/kg for women
• Body mass index (BMI) < 26

Exclusion criteria

• Chronic use of beta2-agonist or allergy towards beta2-agonist
• Serious adverse effects to beta2-agonist
• Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
• Smoking
• Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study
• Pregnancy (for women)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups

beta2-agonist and exercise

Active Comparator group

Description:

Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2)

Treatment:

Other: exercise

Drug: salbutamol

placebo and exercise

Sham Comparator group

Description:

Subjects undergo exercise training with administration of sham placebo

Treatment:

Other: exercise