Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation

Linköping University (LiU)

Status: Unknown

Conditions: Dyspnea; Epigenetic Disorder; Covid19; Cardiopulmonary Disease; Lung Function Decreased

Treatments: Diagnostic Test: Physiological testing

Study type: Observational

Funder types: Other

Identifiers

NCT04859894

2021-01620

Details and patient eligibility

About

The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values. In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.

Full description

The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated. For example, the extent to which subjective symptoms correlate with physiological impairments are not known.

This study will recruit subjects with a clinical diagnosis of Post-Covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. Patients' symptoms will be correlated to physiological measures and compared to predicted values.

In addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or DNA-methylation patterns. In addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed or clinically highly suspected Covid19-infection
• Symptom duration at least 12 weeks following first occurence of symptoms
• No other disease that better could explain the symptoms than Covid19

Exclusion criteria

• Age <18 years
• Unability to perform a maximal exercise test
• Unability to understand written or spoken Swedish

Trial design

150 participants in 1 patient group

Covid19

Description:

Patients aged \>18 years with confirmed Covid19 disease with symptoms \>12 weeks, not better explained by other disease

Treatment:

Diagnostic Test: Physiological testing