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Physiological Values When Breathing in an Air-pocket. Mountain Lab 2019 (ML2019)

H

Haukeland University Hospital

Status

Completed

Conditions

Accident Caused by Snow Avalanche

Treatments

Other: Fresh air

Study type

Interventional

Funder types

Other

Identifiers

NCT03911011
2018/2478

Details and patient eligibility

About

The literature describes and report neurologic intact patients surviving an avalanche several hours after they were buried. The most important factor for surviving more than 15-35 min of burial is considered to be the presence of an air-filled space around the head and neck, termed an air pocket. Little is known how the inspired air is influenced by the patients breathing and how oxygen and carbon dioxide diffuse through snow.

Full description

In a controlled and simulated avalanche scenario the investigators want to investigate how oxygen (O2) and carbon dioxide (CO2) diffuse and how rebreathing of CO2 in addition to mild hypoxia influence standardized physiological parameters in two scenarios: Fresh air and no fresh air delivered into the air pocket. The project is a field study designed to measure and document gas diffusion through snow. The outcome measures are: (1) Concentration of O2 and CO2 in the air pocket and 50 cm from the pocket. (2) Time interval for development of threshold values for concentration of O2 and CO2. The investigators will also monitor physiologic measures such as: Electrocardiogram (ECG), continuous invasive blood pressure, cerebral oximetry, continuous pulse oximetry, transthoracic impedance, and gas content in expired air. Subjective evaluation of comfort will also be scored. Twenty healthy young volunteers with written consent to participate will be used as test subjects.

The study may have a clinical consequence for better outcome, for victims of avalanches by providing additional air or oxygen close to the patient. The study will also measure specific body measures and spirometry.

Enrollment

20 patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Subject must be Healthy
  • Subject must be non smoking
  • Subject must have normal BMI

Exclusion criteria

  • None

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

20 participants in 2 patient groups

Fresh air
Active Comparator group
Description:
2 litres of fresh air
Treatment:
Other: Fresh air
no fresh air
No Intervention group
Description:
no supply of fresh air

Trial contacts and locations

1

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Central trial contact

Oyvind Thomassen, PhD

Data sourced from clinicaltrials.gov

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