PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

Boston Children's Hospital

Status: Enrolling

Conditions: Pneumonia

Treatments: Other: Clinical Stability Assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT06364514

IRB-P00047313

Details and patient eligibility

About

To determine if clinicians can safely reduce antibiotic exposure in children with medical complexity (CMC) who are diagnosed with pneumonia by implementing an intervention that bases total antibiotic duration on an individual's clinical stability.

Enrollment: 50 estimated patients

Sex: All

Ages: 2 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Admitted to the Complex Care Service at Boston Children's Hospital with a provider diagnosis of pneumonia
• Started on antibiotics by the provider team
• Ages 2-25 years old

Exclusion criteria

• Patients initially admitted to the intermediate care unit or ICU due to increased respiratory support needs

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Intervention Group

Experimental group

Description:

Patients will be started on antibiotics for treatment of pneumonia per usual care by their medical provider team. The research team will monitor enrolled patients daily for markers of their clinical status (caregiver assessment of respiratory status, supplemental oxygen/respiratory support, presence of fever). Once the patient has been "clinically stable" x48 hours, antibiotics will be discontinued.

Treatment:

Other: Clinical Stability Assessment