Pilot Data Collection for Activity, Adiposity, and Appetite in Adolescents (AAAA)

Children's Mercy Hospital Kansas City

Status: Completed

Conditions: Metabolism; Physical Activity; Sedentary Lifestyle; Energy Balance

Treatments: Diagnostic Test: Data Collection Procedures

Study type: Observational

Funder types: Other

Identifiers

NCT03157063

16120865

Details and patient eligibility

About

The goal of this study is to quantify energy metabolism using indirect calorimetry at rest, in the presence of excess energy following a meal, and in response to the demand for energy during exercise. The investigators also will examine the individual and joint associations of activity and obesity status on neurocognitive domains of appetite control. Participants will include adolescent males and females (N=80) using a 2 x 2 cross-sectional study design, stratified by body weight (normal vs overweight/obese) and physical activity level (sedentary vs. active).

Full description

The investigators hypothesize that low levels of fitness and MVPA result in impaired metabolic function in adolescents. For this pilot study, the investigators will quantify variations in metabolic characteristics using a 2 x 2 cross-sectional study design, stratified by body weight (normal vs overweight/obese) and physical activity (sedentary vs. active). The goal is to identify metabolic factors that influence the energy balance system to directly inform interventions designed to prevent or reduce the prevalence of pediatric obesity.

Enrollment: 64 patients

Sex: Male

Ages: 14 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males (Tanner Stage III-IV), ages 14-18
• Weight stable (5% weight change) over the previous three months as assessed by self-report.
• BMI greater than 5th and less than 99th percentile
• Physically healthy for exercise as assessed by self report Physical Activity Readiness Questionnaire (PAR-Q) for children.
• For fMRI testing, all participants must be right handed and must have normal or corrected to normal vision (as they will be viewing pictures in the fMRI procedure).

Exclusion criteria

• History of restrained eating, eating disorders, bariatric surgery, or other significant medical diagnosis that could impact metabolism.
• Participants taking thyroid medications, beta blockers, or other stimulants (medications are known to affect physical activity level and metabolism).
• Due to fMRI procedure requirements, children with a history of Attention Deficit Hyperactivity Disorder (ADHD) or other diagnosed psychiatric issues will be excluded.

Trial design

64 participants in 4 patient groups

Inactive, normal weight

Description:

Less than 30 minutes per day of moderate to vigorous physical activity (MVPA), and body mass index percentile (BMI%) between 5th to 75th percentile.

Treatment:

Diagnostic Test: Data Collection Procedures

Inactive, overweight/obese

Description:

Less than 30 minutes per day MVPA, BMI% between 85th and 99th.

Treatment:

Diagnostic Test: Data Collection Procedures

Active, normal weight

Description:

More than 60 minutes per day MVPA, BMI% between 5th and 75th.

Treatment:

Diagnostic Test: Data Collection Procedures

Active, overweight/obese

Description:

More than 60 minutes per day MVPA, BMI% between 85th and 99th.

Treatment:

Diagnostic Test: Data Collection Procedures