Pilot Project of Adaptive Thoracic Radiotherapy for Small Cell Lung Cancer

AHS Cancer Control Alberta

Status and phase

Unknown

Phase 1

Conditions

Small Cell Lung Cancer

Treatments

Radiation: Adaptive Radiation

Study type

Interventional

Funder types

Other

Identifiers

NCT01426841

CCI Yee 25708

Details and patient eligibility

About

This study is intended to assess the feasibility of adjusting a radiation plan during its course to accommodate for a shrinking tumor target. The investigators hypothesize that an adaptive radiotherapy (RT) planning strategy for small cell lung cancer (SCLC) patients with chest-confined disease will allow for safe delivery of higher doses of chest RT than a non-adaptive RT planning approach without subjecting normal critical structures to unacceptable doses of radiotherapy.

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with histologically or cytologically proven newly diagnosed small cell lung cancer
chest-confined disease (including bulky intrathoracic disease)
adequate pulmonary function tests (FEV-1>1.0 L, DLCO>50%)
patients of childbearing potential must practice adequate contraception
Age > or = 18 years
Karnofsky performance status > or = 70
eligible for concurrent chemoradiotherapy

Exclusion criteria

patients who have undergone complete or subtotal tumour resection
evidence of non-small cell histology
prior or concurrent malignancy except non-melanomatous skin cancer unless disease-free for at least 5 years
prior RT to the thorax or neck
compromised lung function with inadequate pulmonary function tests (FEV-1<1.0,DLCO<50%)
pregnant women