Pilot Study Comparing Ventilation Modes During CPR With Mechanical Compression Device. (COVME)

Technical University of Munich

Status: Completed

Conditions: Cardiopulmonary Resuscitation

Treatments: Procedure: Volume controlled ventilation; Procedure: Pressure controlled ventilation; Procedure: CPAP mode

Study type: Interventional

Funder types: Other

Identifiers

NCT03347175

COVME

Details and patient eligibility

About

Comparison of three ventilation modes (volume controlled, BIPAP and CPAP) during cardiopulmonary re-suscitation with a mechanical compression device in the emergency room. Primary aim is to assess mean ventilation volume in the first 15 minutes after randomization.

Full description

Mechanical compression devices are applied to grant continuous chest compressions and consequently blood flow during CPR (cardiopulmonary rescuscitation). Current guidelines, however, are lacking guidance of the optimal ventilation strategy in such scenarios. This may lead to lung injuries caused by high pressure levels in the chest while applying compression and ventilation simultaneously or hypoventilation. Consequently, this pilot study assesses iwhich ventilation mode is optimal. Patients will be assigned randomly to one of the three ventilation modes (Volume controlled, BiPAP-ASB, CPAP). Ventilation parameters will be continuously monitored for 15 minutes while blood gas analyses are taken as well. Further secondary outcome parameters will be assessed, e.g. hospital mortality.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• On-going out of hospital CPR in the Emergency Room
• Tracheal intubated
• Use of mechanical chest compression device

Exclusion criteria

• If the treating team assumes that CPR will be ceased within the next 15 minutes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Volume controlled ventilation

Experimental group

Description:

Intervention1: Ventilation with Volume controlled ventilation

Treatment:

Procedure: Volume controlled ventilation

Pressure controlled ventilation

Active Comparator group

Description:

Intervention2: Ventilation with Pressure controlled ventilation

Treatment:

Procedure: Pressure controlled ventilation

CPAP mode

Active Comparator group

Description:

Intervention3: Ventilation with Continuous Positive Airway Pressure mode only

Treatment:

Procedure: CPAP mode