Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

Rockefeller University

Status: Completed

Conditions: Obesity

Treatments: Procedure: Fat Biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT01900366

JAL-0809

Details and patient eligibility

About

This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

Full description

Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Enrollment: 14 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion criteria

-History of any skin disease

Trial design

14 participants in 2 patient groups

Obese subjects for fat biopsy

Description:

10 patients recruited during fat biopsies for sample collection

Treatment:

Procedure: Fat Biopsy

Lean controls for fat biopsy

Description:

5 Lean controls will be recruited

Treatment:

Procedure: Fat Biopsy