Pilot Study of 18F-FLT PET

University of Wisconsin (UW)

Status

Terminated

Conditions

Esophageal Cancer

Lung Cancer

Head and Neck Cancer

Prostate Cancer

CNS Brain Metastasis

Treatments

Procedure: Imaging with 18F-FLT PET

Study type

Interventional

Funder types

Other

Identifiers

NCT00585741

HSC-2006-0280

Details and patient eligibility

About

Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission

Enrollment

15 patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Able to tolerate a PET/CT scan
Age of 18 or older
signed informed consent
being considered for radiotherapy for treatment of CNS mets, Head and neck cancer, lung cancer, prostate cancer or esophageal cancer

Exclusion criteria

Prior XRT to site being studied
severe claustrophobia or inability to tolerate PET/CT
unable to provide written consent
pregnant or breastfeeding women

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

15 participants in 5 patient groups

2. Head and neck

Experimental group

Description:

Imaging with 18F-FLT PET

Treatment:

Procedure: Imaging with 18F-FLT PET

3. Lung

Experimental group

Description:

Imaging with 18F-FLT PET

Treatment:

Procedure: Imaging with 18F-FLT PET

4. prostate

Experimental group

Description:

Imaging with 18F-FLT PET

Treatment:

Procedure: Imaging with 18F-FLT PET

5. esophagus

Experimental group

Description:

Imaging with 18F-FLT PET

Treatment:

Procedure: Imaging with 18F-FLT PET

1.CNS

Experimental group

Description:

Imaging with 18F-FLT PET

Treatment:

Procedure: Imaging with 18F-FLT PET

Trial contacts and locations

1

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