Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients

University of Wisconsin (UW)

Status: Terminated

Conditions: Esophageal Cancer; Lung Cancer; CNS Brain Metastases; Head and Neck Cancer; Prostate Cancer

Treatments: Procedure: PET-imaging with CuATSM; Procedure: PET imaging with CuATSM; Procedure: PET Imaging; Procedure: PET imaging; Procedure: PET CuATSM

Study type: Interventional

Funder types: Other

Identifiers

NCT00585117

A533300 (Other Identifier)

RO06309 (Other Identifier)

HSC 2006-0282

SMPH\HUMAN ONCOLOGY\HUMAN ONCO (Other Identifier)

Details and patient eligibility

About

Hypoxia is a key factor in malignant progression of a neoplasm. It is our aim to explore the basis for quantitative in vivo tumor imaging by Cu-61 diacetyl-bis(N4-methylthiosemicarbazone)PET imaging as a surrogate of tissue hypoxia. We hypothesize that the hypoxia levels are predictive of the tumor response to therapy. Patients will have 2 CU-ATSM PET scans done and the goal is to show spatially stable tracer distributions that correlate with tumor hypoxia. This study will serve as a pilot study for a PO1 submission

Enrollment: 9 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Able to tolerated a PET/CT scan
• Age 18 or older
• Patient being considered for XRT for treatment of their cancer
• Able to provide written informed consent

Exclusion criteria

• severe claustrophobia or inability to tolerate the PET scan
• pregnant or breastfeeding women
• Patients that need supplemental oxygen
• Patients enrolled in experimental treatments

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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9 participants in 5 patient groups

1 CNS

Experimental group

Description:

imaging with CuATSM

Treatment:

Procedure: PET-imaging with CuATSM

Procedure: PET Imaging

2. Head and Neck

Experimental group

Description:

Imaging with CuATSM

Treatment:

Procedure: PET CuATSM

3. Lung

Experimental group

Description:

imaging with CuATSM

Treatment:

Procedure: PET imaging

4. Prostate

Experimental group

Description:

PET imaging with CuATSM

Treatment:

Procedure: PET imaging with CuATSM

Procedure: PET imaging with CuATSM

5. Esophagus

Experimental group

Description:

PET imaging with CuATSM

Treatment:

Procedure: PET imaging with CuATSM

Procedure: PET imaging with CuATSM