Pilot Study of Alternative Treatments of Unexplained Chronic Fatigue

Utah System of Higher Education (USHE)

Status: Terminated

Conditions: Myalgic Encephalomyelitis; Idiopathic Chronic Fatigue; Chronic Fatigue Syndrome

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00983502

R21AT004537-02 (U.S. NIH Grant/Contract)

25988

Details and patient eligibility

About

The investigators' long-term goal is to identify, and then provide general practitioners with evidence-based recommendations for therapeutic interventions for unexplained chronic fatigue (UCF). The investigators' central hypothesis guiding this application is that some complimentary and alternative medicine (CAM) practitioners have developed management approaches that are more helpful to patients with UCF than usual care.

Full description

An objective is to identify certain types of clinicians (or individual physicians) who appear to have identified effective treatments for patients with UCF, or to find that clinicians who report themselves to be effective are not. Study subjects will be UCF patients new to the practice of one of four groups of participating clinicians: 1) a control group of MDs in practice-based research networks, 2) MDs trained in CAM, 3) naturopathic doctors (non MDs trained in special naturopathic schools), and 4) MDs who specialize in chronic fatigue. Our rationale for this comparison is that its successful completion will potentially guide future searches for effective medical strategies for the treatment of UCF that may have been developed outside the mainstream medical community. It may also provide necessary information for follow-up studies that will help to identify specific effective treatments. This information includes which clinicians provide the best treatments (as evidenced by having patients with the best results), what are the characteristics of patients who respond to a particular treatment, how the data collection procedures might need to be refined and what sample sizes are necessary.

Enrollment: 154 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age 21 through 65.
2. Has severe debilitating fatigue that substantially reduces the quality of life.
3. Does not have any organic, psychological, or lifestyle problems that are the primary disorder and are likely to be the cause of this fatigue (see exclusionary criteria)
4. The severe, unexplained fatigue has persisted for at least six months.
5. Has not been previously treated by current physician for chronic fatigue.
6. Can speak and read English.
7. Is not pregnant or planning to become pregnant within six months.
8. Has a telephone.

Exclusion criteria

No known history of:

1. Bipolar disorder
2. Psychosis
3. Major Depressive Disorder
4. Sleep disorder
5. Anemia
6. Thyroid disease
7. Rheumatoid Arthritis
8. Systemic Lupus
9. Cancer
10. Heart disease
11. Liver disease

Trial design

154 participants in 4 patient groups

Integrative Medicine

Description:

Patients of MD practitioners trained in Complementary and Alternative Medicine

Naturopath Doctors

Description:

Patients of practitioners who are not MD's and are trained in Naturopathic Medicine

Chronic Fatigue Specialists

Description:

Patients of MD's who specialize in treating Chronic Fatigue and related conditions

Control Group

Description:

Patients treated by primary care MDs in practice-based research networks