Pilot Study of Colon Cancer Screening Tests

Hamilton Health Sciences (HHS)

Status: Terminated

Conditions: Adenomatous Polyps; Colon Cancer; Colorectal Cancer

Treatments: Other: Fecal occult blood test; Procedure: Virtual colonoscopy; Procedure: Optical colonoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT00865527

CTC1.0

Details and patient eligibility

About

Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options for colon cancer screening, but it is not known which is the best at preventing death from colon cancer. A large study comparing these three tests is desperately needed. In this pilot study, the investigators want to find out what percentage of patients will show up for their screening test once enrolled. This will provide crucial information for the successful execution of the larger study.

Enrollment: 198 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All individuals age 50 to 70 years

Exclusion criteria

• Unable to give informed consent
• History of colorectal cancer
• History of adenomatous polyp
• History of inflammatory bowel disease
• Prior participation in FOBT screening
• Prior refusal to participate in FOBT screening
• Flexible sigmoidoscopy within the previous 3 years
• Virtual colonoscopy within the previous 3 years
• Optical colonoscopy within the previous 3 years
• Severe of terminal illness that would preclude benefit from colon cancer screening

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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198 participants in 3 patient groups

Fecal Occult Blood Test

Active Comparator group

Description:

fecal occult blood test

Treatment:

Other: Fecal occult blood test

Virtual Colonoscopy

Active Comparator group

Description:

virtual colonoscopy

Treatment:

Procedure: Virtual colonoscopy

Optical Colonoscopy

Active Comparator group

Description:

optical (conventional / endoscopic) colonoscopy

Treatment:

Procedure: Optical colonoscopy