Pilot Study of Hippocampal Function in Type 1 Diabetes Mellitus (T1DM) (ASSET)

The Washington University

Status: Completed

Conditions: Type 1 Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT00918801

06-0786

Details and patient eligibility

About

This study is an expansion of a previous study done to determine how thinking skills relate to hypoglycemia (low blood sugar) and certain regions of the brain in children and adolescents. In this study, the investigators are testing thinking skills and measuring brain activity in adolescents with and without type 1 diabetes mellitus.

Enrollment: 91 patients

Sex: All

Ages: 13 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 13 - 18
• Right handed
• Diagnosis of Type 1 Diabetes OR normal sibling control
• If diabetic, then diagnosis for at least 2 years

Exclusion criteria

• Pregnant or lactating
• Chronic disease other than well-controlled asthma, or Hashimoto's thyroiditis.
• Other current serious medical illness
• Co-morbid psychiatric illness
• Co-morbid neurological illness
• Pre-maturity at birth
• Contraindication to MRI scan
• orthodontic braces.

Trial design

91 participants in 2 patient groups

Type 1 Diabetes Mellitus

Description:

Adolescents ages 13-18 with T1DM

Non Controls

Description:

Healthy adolescents ages 13-18 without T1DM