Pilot Study of Maintenance Therapy With Intravenous AMANTADINE

Clalit Health Services

Status: Unknown

Conditions: Parkinson Disease

Treatments: Drug: Amantadine

Study type: Interventional

Funder types: Other

Identifiers

NCT01190553

0166-10-RMC

Details and patient eligibility

About

This is a pilot study for Maintenance Intravenous Treatment with AMANTADINE in patient with PARKINSON'S Disease who are not well balanced with medical treatment.

Enrollment: 20 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with idiopathic Parkinson disease
• Age<80
• Patients with no motor improvement under optimal treatment with anti parkinson medications
• Patients with moderate to severe dyskinesias
• Patients with PD with side effects who can not tolerate anti parkinson medications

Exclusion criteria

• Age>80
• Patients with Parkinson syndromes, vascular parkinsonism or drug-induced parkinsonism
• Patients with PD who developed adverse reactions to oral amantadine
• Contraindication of amantadine treatment

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

20 participants in 1 patient group

Treatment

Experimental group

Description:

IV amantadine treatment

Treatment:

Drug: Amantadine