Pilot Study of Myocardial Effects Following an Endurance Race

University Hospital, Linkoeping

Status: Unknown

Conditions: Myocardial Blood Flow

Treatments: Behavioral: Endurance Race

Study type: Interventional

Funder types: Other

Identifiers

NCT03549364

2017/429-31

Details and patient eligibility

About

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests for myocardial injury and inflammation.

The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow.

Full description

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests (troponin T, hs-CRP, CK-mb etc) for myocardial injury and inflammation.

The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging (MRI) is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow. The CT of the heart includes contrast injection and blood flow will be determined by a recently developed based on very powerful computers using "machine learning".

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy subjects, experienced in long distance running

Exclusion criteria

Significant renal, kidney, heart, liver or musculoskeletal disease.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Endurance race

Experimental group

Description:

1. baseline investigations with CT and lab tests 2. the same CT and lab tests \< 24h after an endurance race 3. CT and lab tests again about 1-2weeks after the race

Treatment:

Behavioral: Endurance Race