Pilot Study of New Computer-based Neuropsychological Tool: Visual Tests, Touch Responses

NYU Langone Health

Status: Enrolling

Conditions: Cerebral Neurological Illness

Treatments: Diagnostic Test: Symbol Span subtest of the Wechsler Memory Scale-IV; Diagnostic Test: Dot Counting Test; Diagnostic Test: Judgment of Line Orientation; Diagnostic Test: Railroad Test; Diagnostic Test: Presidents Recognition Test; Diagnostic Test: Symbol Digit Modalities Test:; Diagnostic Test: Reading subtest of the Wide Range Achievement Test; Diagnostic Test: Swamp Test; Diagnostic Test: Digit Span subtest of the Wechsler Adult Intelligence Scale-I; Diagnostic Test: Information subtest of the Wechsler Adult Intelligence Scale-IV:

Study type: Interventional

Funder types: Other

Identifiers

NCT03502603

17-01677

Details and patient eligibility

About

This study is aimed at investigating three new tests that will form part of a computerized tool designed to test brain/cognitive functioning. The system will be evaluated along with the tests' usability on samples of healthy controls and neurologically impaired patient participants. These new tests will be assessed with regard to reliability and validity. Reliability will be addressed through investigation of internal consistency of the test items. Validity will be evaluated relative to traditional paper-and-pencil tests and differentiation between patient and healthy participants.Each participant will complete both the computerized and paper and pencil-based tests. The results will be analyzed to see how performances on the two test types compare. The overall aim of this project is to determine if these new computerized tasks are an improvement over standard paper and pencil-based neuropsychological measures.

Enrollment: 200 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Individuals without positive cerebral findings on neuroimaging (Non-PCF)

• Participants can be male or female and between the ages of 21 and 65 years old.
• Participants will have adequate perceptual and motor capabilities to participate in testing.

Neuroimaging-positive cerebral findings (PCF)

• Patients at NYULMC identified to have significant cerebral findings on neuroimaging.
• Participants will be male or female and between the ages of 21 and 65 years old.
• Participants will have adequate perceptual and motor capabilities to participate in testing.

Exclusion criteria

• Participants without adequate perceptual and motor capacities preventing them from participation in the testing.
• Participants with severe dysfunction at the level of dementia that can interfere with informed consent.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Cerebral neurological illness (CNI) participants

Active Comparator group

Description:

Identified from the department of Rehabilitation, Psychiatry, and Medicine and referred to the research staff via in-person communication, email or staff message

Treatment:

Diagnostic Test: Information subtest of the Wechsler Adult Intelligence Scale-IV:

Diagnostic Test: Digit Span subtest of the Wechsler Adult Intelligence Scale-I

Diagnostic Test: Swamp Test

Diagnostic Test: Reading subtest of the Wide Range Achievement Test

Diagnostic Test: Symbol Digit Modalities Test:

Diagnostic Test: Presidents Recognition Test

Diagnostic Test: Railroad Test

Diagnostic Test: Judgment of Line Orientation

Diagnostic Test: Dot Counting Test

Diagnostic Test: Symbol Span subtest of the Wechsler Memory Scale-IV

Non-CNI participants

Active Comparator group

Description:

Identified from the department of Rehabilitation, Psychiatry, and Medicine and referred to the research staff via in-person communication, email or staff message

Treatment:

Diagnostic Test: Information subtest of the Wechsler Adult Intelligence Scale-IV:

Diagnostic Test: Digit Span subtest of the Wechsler Adult Intelligence Scale-I

Diagnostic Test: Swamp Test

Diagnostic Test: Reading subtest of the Wide Range Achievement Test

Diagnostic Test: Symbol Digit Modalities Test:

Diagnostic Test: Presidents Recognition Test

Diagnostic Test: Railroad Test

Diagnostic Test: Judgment of Line Orientation

Diagnostic Test: Dot Counting Test

Diagnostic Test: Symbol Span subtest of the Wechsler Memory Scale-IV