Pilot Study of Organic Nitrates on Endothelial Function in CAD Patients (ONEEF)

Julius-Maximilians University

Status: Unknown

Conditions: Coronary Artery Disease

Treatments: Drug: PETN, ISDN

Study type: Interventional

Funder types: Other

Identifiers

NCT01030367

0001

Details and patient eligibility

About

Organic nitrates increase levels of circulating endothelial progenitor cells (Thum et al., Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):748-54). Here, we want to test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function.

Full description

In this pilot study we test the effects of two different organic nitrates (PETN, ISDN) on number and function of endothelial progenitor cells and endothelial function. These parameters will be measured before and after 14d of treatment.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary artery disease, 2- or 3-vessel disease

Exclusion criteria

• Acute myocardial infarction, acute heart failure, cancer, acute infections

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 3 patient groups

1

Experimental group

Description:

PETN

Treatment:

Drug: PETN, ISDN

2

Experimental group

Description:

ISDN

Treatment:

Drug: PETN, ISDN

3

No Intervention group

Treatment:

Drug: PETN, ISDN