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Pilot Study of Protein Profiling of the Human Epidermal Cells After Ultraviolet Irradiation

University of Minnesota (UMN) logo

University of Minnesota (UMN)

Status and phase

Completed
Early Phase 1

Conditions

Proteomics

Treatments

Procedure: UV Irradiation

Study type

Interventional

Funder types

Other

Identifiers

NCT00397436
0506M70827

Details and patient eligibility

About

The main focus of this pilot study is to construct a fairly complete protein profile of the epidermis. This will allow us to study how the epidermis responds to external stressors such as ultra-violet. We hypothesize that by using the cutting edge technology, proteomics, we will be able to construct a fairly complete profile of different epidermal cells (keratinocytes, epidermal nerve fibers (ENFs), melanocytes, Langerhans cell,...etc) of normal and ultraviolet (UV) irradiated skin.

Full description

We will investigate the changes of the epidermal cell proteome after UV irradiation to the forearms of healthy young male volunteers. Knowledge of specific molecular markers may provide knowledge of basic biological systems and possibly targeted therapy of inflammation.

By using combined proteomic methodologies we will be able to quantify protein changes at cytoplasmic and membrane protein levels of epidermal cells in normal vs. irradiated skins.

This study may allow us to obtain fairly comprehensive profile of membrane integrated and cytoplasmic proteins of epidermal cell populations which will facilitate our understand of biological responses to UV irradiation.

Enrollment

60 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy Males age 18-30
  • Caucasian
  • No neurological disease

Exclusion criteria

  • Use of any medication that affects skin

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

60 participants in 1 patient group

1
Experimental group
Description:
Comparing irradiated skin to non irradiated skin.
Treatment:
Procedure: UV Irradiation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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