Pilot Study of Remote Ischemic Preconditioning in Heart Failure

University Health Network, Toronto

Status: Completed

Conditions: Heart Failure; Left Ventricular Dysfunction

Treatments: Other: Remote ischemic preconditioning; Other: Sham Control

Study type: Interventional

Funder types: Other

Identifiers

NCT01128790

09-0550-BE

Details and patient eligibility

About

The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• LV ejection fraction <40%
• NYHA functional class II-IV
• Non ischemic cardiomyopathy
• Stable

Exclusion criteria

• recent cardiovascular hospitalization (within last 4 weeks)
• ischemic cardiomyopathy
• diabetes mellitus
• peripheral neuropathy
• ventricular assist device
• contraindications to exercise stress testing

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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22 participants in 2 patient groups

remote ischemic preconditioning

Experimental group

Description:

4 cycles of 5 mins upper limb ischemia induced by blood pressure cuff inflation 20mmHg above systolic blood pressure

Treatment:

Other: Remote ischemic preconditioning

Sham control

Sham Comparator group

Description:

4 x 5 mins of upper limb blood pressure cuff inflation to 10mmHg (non-occlusive)

Treatment:

Other: Sham Control