Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment (Mask_MRI)

Weill Cornell Medicine (WCM)

Status: Completed

Conditions: Obstructive Sleep Apnea (OSA)

Treatments: Device: Nasal and Oronasal PAP Mask

Study type: Interventional

Funder types: Other

Identifiers

NCT01939938

1207012713

Details and patient eligibility

About

Our group has recently found that the choice of positive airway pressure mask can significantly affect the pressure required to adequately treat sleep disordered breathing. The goal of this study is to visualize the upper airway in the retropalatal and retroglossal region while using both oronasal and nasal masks with CPAP in order to investigate differences in upper airway dynamics that may occur between these two mask types.

Full description

It is known that oronasal masks are not as effective at opening the upper airway compared to nasal only continuous positive airway pressure (CPAP) masks in patients with sleep-disordered breathing. However, the physiological mechanism for this difference in efficacy is not known; although, it has been hypothesized to involve the retroglossal and/or retropalatal region of the upper airway. The objective of this study was to investigate differences in retroglossal and retropalatal anterior-posterior space with the use of oronasal vs. nasal CPAP masks using real-time cine magnetic resonance imaging (cMRI).

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• AHI> 30/hr
• 18-75 years of age

Exclusion criteria

• History of claustrophobia
• History of pacemaker, nerve stimulator, or any other metal implanted device

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

All Subjects-Nasal and Oronasal PAP Mask

Experimental group

Description:

Each subject will be imaged in a dynamic MRI with both a oronasal and nasal mask at pressures of 5, 10, and 15 cm of H2O.

Treatment:

Device: Nasal and Oronasal PAP Mask