Pilot Study Of Unrelated UCB Transplant for Non-Malignant Hematologic Conditions

Case Comprehensive Cancer Center (Case CCC)

Status and phase: Completed; Phase 2

Conditions: Leukemia; Myelodysplastic/Myeloproliferative Diseases; Myelodysplastic Syndromes

Treatments: Procedure: bone marrow ablation with stem cell support; Drug: busulfan; Drug: methylprednisolone; Procedure: umbilical cord blood transplantation; Radiation: radiation therapy; Drug: cyclophosphamide; Drug: melphalan; Biological: anti-thymocyte globulin

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00003336

CASE-CWRU-5Y97

NCI-G98-1431

P30CA043703 (U.S. NIH Grant/Contract)

CWRU5Y97

CASE-5Y97

Details and patient eligibility

About

RATIONALE: Umbilical cord blood transplantation may allow doctors to give higher doses of chemotherapy or radiation therapy and kill more cancer cells.

PURPOSE: This phase II trial is studying how well umbilical cord blood transplantation works in treating patients with severe aplastic anemia, malignant thymoma, or myelodysplasia.

Full description

OBJECTIVES:

• Determine the rates of durable engraftment in patients with severe aplastic anemia, myelodysplastic syndrome, inborn errors of metabolism, or inherited hematopoietic disorders, refractory to medical management, who are undergoing high-dose chemoradiotherapy followed by unrelated cord blood (UCB) transplantation.
• Evaluate the rate and quality of immunologic reconstitution in this patient population.

OUTLINE: Patients are stratified according to weight (under 45 kg vs over 45 kg).

Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT). The regimen varies according to the underlying cause of the anemia, but could include busulfan, cyclophosphamide or melphalan, anti-thymocyte globulin or methylprednisolone, and/or radiation therapy. One day after the conditioning regimen is completed, patients receive the UCBT.

Patients are followed weekly for 3 months, at 6 months, then every 6 months for 2.5 years, then annually thereafter.

PROJECTED ACCRUAL: A total of 4-90 patients will be accrued for this study within 5 years.

Enrollment: 6 patients

Sex: All

Ages: Under 55 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed diagnosis of severe aplastic anemia based on bone marrow cellularity of less than 20%

• Must meet at least two of the following criteria:

  • Granulocyte count less than 500/mm^3
  • Platelet count less than 20,000/mm^3
  • Reticulocyte count less than 50,000/mm^3

• Following etiologies eligible:

  • Fanconi's anemia
  • Hypoplastic leukemia
  • Monosomy 7
  • Drug exposure (chloramphenicol, NSAIDS)
  • Viral exposure (EBV, hepatitis, parvovirus, HIV)
  • Nutritional deficiencies
  • Thymoma
  • Paroxysmal nocturnal hemoglobinuria
  • Amegakaryocytic thrombocytopenia OR

• Histologically confirmed myelodysplastic syndrome (MDS) that is refractory to medical management or with cytogenic abnormalities predictive of transformation into acute leukemia, including 5q-, 7q-, monosomy 7, or trisomy 8

• The following etiologies only are eligible:

  • Refractory anemia
  • Refractory anemia with ringed sideroblasts
  • De novo primary MDS
  • Therapy-related secondary MDS OR

• Confirmed diagnosis of inherited hematopoietic disorder that is refractory to medical management

• Following etiologies eligible:

  • Severe combined immunodeficiency
  • Familial erythrophagocytic lymphohistiocytosis
  • Wiskott-Aldrich syndrome
  • Kostmann's syndrome (infantile histiocytosis)
  • Chronic granulomatous disease
  • Leukocytic adhesion deficiency
  • Chediak-Higashi syndrome
  • Paroxysmal nocturnal hemoglobinuria
  • Fanconi's anemia
  • Dyskeratosis congenita
  • Diamond-Blackfan anemia
  • Amegakaryocytic thrombocytopenia
  • Osteopetrosis
  • Gaucher's disease
  • Lesch-Nyhan syndrome
  • Mucopolysaccharidoses
  • Lipodoses

• Autologous or haploidentical related peripheral blood stem cells available as backup

• Serologically matched umbilical cord blood unit available in the New York Blood Center's Placental Blood Project, or other acceptable umbilical cord blood registry

PATIENT CHARACTERISTICS:

Age:

• 55 and under

Performance status:

• Zubrod 0-1
• Karnofsky 80-100%

Life expectancy:

• At least 3 months

Hematopoietic:

• See Disease Characteristics

Hepatic:

• ALT/AST no greater than 4 times normal
• Bilirubin no greater than 2.0 mg/dL

Renal:

• Creatinine no greater than 2.0 mg/dL
• Creatinine clearance at least 50 mL/min

Cardiovascular:

• Normal cardiac function by echocardiogram or radionuclide scan
• Shortening fraction or ejection fraction at least 80% normal for age
• Non-Fanconi patients with acquired or congenital cardiomyopathy may receive melphalan as a substitute for cyclophosphamide

Pulmonary:

• FVC and FEV_1 at least 60% of predicted for age
• DLCO at least 60% of predicted in adult patients

Other:

• No active concurrent malignancy
• No active infection
• Not pregnant or nursing
• HIV negative
• Must have an available serologic matched Umbilical Cord Blood Unit (UCBU) in the New York Blood Center's Placental Blood Project, or other acceptable Umbilical Cord Blood (UCB) registry

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No concurrent cytotoxic chemotherapy

Endocrine therapy:

• No concurrent immunosuppressive medications

Radiotherapy:

• No concurrent radiotherapy

Surgery:

• Not specified

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)