Pilot Study on the Tolerability of Dietary Dried Plum

University of California San Francisco (UCSF)

Status: Completed

Conditions: Healthy; Elderly

Treatments: Dietary Supplement: dried plum powder

Study type: Interventional

Funder types: Other

Identifiers

NCT01035372

H592-34987-01

Details and patient eligibility

About

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

Enrollment: 6 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 50 yrs and 75 yrs
• Nonsmokers
• Normal renal and hepatic function

Exclusion criteria

• Subjects who must follow a specific diet
• Subjects on any daily medications that affect bone health
• Subjects too heavy for the DEXA machine (weight limit 300 lbs)
• Subjects whose BMD by DEXA indicates osteoporosis
• Subjects unwilling to follow the diet specified
• Pregnant women
• Subjects who are unable to understand the consent form.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

dried plum

Experimental group

Description:

subjects will have 25% by weight (\~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder

Treatment:

Dietary Supplement: dried plum powder