Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive Crisis (DREPP)

Grenoble Alpes University Hospital Center (CHU)

Status: Not yet enrolling

Conditions: Sickle Cell Disease

Treatments: Other: Pleuropulmonary ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT06755385

38RC24.0347

Details and patient eligibility

About

Describe the proportion of patients with major sickle cell syndrome in vaso-occlusive crisis presenting at least one pleuropulmonary ultrasound abnormality during one of the ultrasounds performed at D0, between D2 and D5 during hospitalization and at D-1 of discharge.

We hypothesize that pleuropulmonary ultrasound will make it possible to detect the serious complications associated with vaso-occlusive crises in patients with major sickle cell syndrome earlier and more reliably, in departments where ultrasound tools are still underdeveloped, while avoiding the need for more conventional radiology examinations that cause radiation in multi-hospitalized patients.

Enrollment: 25 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient agreeing to participate in the study
• Patient with sickle-cell disease consulted to the emergency department or hospitalized in a conventional internal medicine department for a clinical picture of severe vaso-occlusive crisis (CVO) requiring hospitalization.
• Hospitalization in the internal medicine department
• Possible re-inclusion in the event of a subsequent episode of severe CVO

Exclusion criteria

• Subject under guardianship or subject deprived of freedom.
• Primary acute chest syndrom (not following a crisis)
• Pulmonary pathologies interfering with pleuro-pulmonary echo analysis: pneumonectomy, pulmonary fibrosis.