Pink Esthetic Score Around Immediate Implants Using PDDM as Jumping Gap Filling Material.

Cairo University (CU)

Status: Not yet enrolling

Conditions: Prostheses; Endosseous Dental Implant Failure

Treatments: Procedure: Immediate implant

Study type: Interventional

Funder types: Other

Identifiers

NCT05952765

7691

Details and patient eligibility

About

Will there be a difference in Pink Esthetic score and soft tissue changes around immediate implants in maxillary esthetic zone following grafting the jumping gap with partially demineralized dentin matrix compared with xenograft?

Full description

This study aims to evaluate the soft tissue changes as well as hard tissue changes around immediate implants in maxillary esthetic zone following grafting the jumping gap with partially demineralized dentin matrix in comparison to xenograft.

Because xenogeneic bone is so readily available in substantial quantities, it has been the subject of notable research. However, because they contain organic material from a foreign species, xenogeneic bones are inherently very antigenic.

According to experimental results, PDDM encourages bone regeneration in a manner like autogenous bone. Both cortical bone and autogenous tooth grafts share similar physical and chemical characteristics, including optimal biodegradability, not requiring a separate surgery to harvest the graft and space maintenance capabilities. PDDM is a valuable comparator to autogenous bone in ARP and around dental implants in guided bone regeneration procedures

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients above 18 years of age; with non-restorable teeth requiring replacement with immediate implants in the maxillary esthetic zone.
• Absence of active infection at the surgical site.
• Adequate primary stability following immediate implant placement.
• Intact socket walls following the extraction.
• Class I dental socket based on a preoperative CBCT scan
• Buccal plate thickness more than 1 mm and thick biotype.
• Compliant patients who will sign an informed consent and agree to the follow up period.

Exclusion criteria

• Poor oral hygiene or the lack of regular maintenance.
• Individuals with compromised immune system or debilitating systemic disease.
• The presence of parafunctional habits (bruxism or clenching).
• External root resorption.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Partially demineralized dentin matrix graft

Experimental group

Description:

* A high-speed fine finishing stone and saline irrigation will be used to clean extracted teeth from periodontal ligaments, soft tissue attachments, caries, and restorations if present. * Teeth particles will be partially demineralized using nitric acid 2% for fifteen minutes. * Finally, the prepared partially demineralized dentin matrix graft granules will be washed twice with distilled water and phosphate buffered saline * Immediate implant of appropriate dimensions will be placed and the previously prepared partially demineralized dentin matrix graft will be used to graft the jumping gap. * Customized healing abutment will be used. * In Osseo integrated implants temporary abutment will be removed and impressions for final restoration will be performed after 3 months.

Treatment:

Procedure: Immediate implant

xenograft

Active Comparator group

Description:

* After tooth extraction, thorough curettage will be performed. * Immediate implant of appropriate dimensions will be placed, and the jumping gap will be grafted with xenograft "Cerabone" . * Customized healing abutment will be used. * In Osseo integrated implants temporary abutment will be removed and impressions for final restoration will be performed after 3 months.

Treatment:

Procedure: Immediate implant