Pioglitazone on Viral Kinetics, Cytokines and Innate Immunity in Insulin Resistant CHC GT 1 Subjects

Brooke Army Medical Center

Status

Completed

Conditions

Chronic Hepatitis C

Treatments

Drug: Pioglitazone (Actos)

Study type

Interventional

Funder types

Other

Other U.S. Federal agency

Identifiers

NCT00926016

C.2006.152

Details and patient eligibility

About

The purpose of this study is to determine if rosiglitazone, a medicine used to treat diabetes, improves response to anti-viral treatment.

Full description

The aim of the study will be to determine if an insulin sensitizing thiazolidinedione (TZD) improves (1) baseline viremia, (2) enhances viral kinetics, (3) improves cytokine profiles and (4) up regulates innate cellular immunity (presumably adaptive immunity is up regulated as well) as measured by the bioactivity of the collected biomarkers.

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

HCV-Ab or HCV-RNA by PCR Positive for at least six months (to rule out acute seroconversion)
Serum positive for HCV-RNA by PCR assay
Must have insulin resistance, defined as a QUICKI score < 0.35. QUICKI
Liver biopsy consistent with CHC within 24 months prior to enrollment
Compensated liver disease with the following minimum hematological, biochemical, and serologic criteria at the Screening Visit (WNL = within normal limits):
- Hemoglobin values of >12 gm/dL for females and >13 gm/dL for males.
- WBC >3,000/ mm3
- Neutrophil count > 1,500/mm3
- Platelets >65,000/ mm3
- Direct bilirubin, within 20% of ULN
- Indirect bilirubin, within normal limits (WNL)
- Albumin >3gm/dL
- Serum creatinine < 20% above the ULN
- TSH WNL
- Alpha fetoprotein value < 100 ng/mL

Exclusion criteria

Prior interferon based therapy
Use of insulin
Fasting glucose levels > 200 mg/dl
Women who are pregnant or breast-feeding
No other thiazolidinedione after liver biopsy and/or during the entire study (
Hepatitis C of non-genotype 1
Suspected hypersensitivity to pioglitazone
Any cause for liver disease other than chronic hepatitis C, insulin resistance, or NAFLD, including but not limited to:
- Hemochromatosis
- Alpha-1 antitrypsin deficiency
- Co-infection with HBV
- Wilson's disease
- Autoimmune hepatitis
- Significant alcohol use
- Drug-related liver disease
Any condition that would prevent the subject from having a liver biopsy.
Hemoglobinopathies that could potentially compromise patient safety
Evidence of advanced liver disease such as history or presence of ascites, bleeding varices, spontaneous encephalopathy.
Participants with organ transplants other than cornea and hair transplant.
Any known preexisting medical condition that could interfere with the subject's participation in and completion of the protocol such as:
- Preexisting psychiatric condition, especially severe depression, or a history of severe psychiatric disorder, such as major psychoses, suicidal ideation and/or suicidal attempt are excluded
- Substance abuse, such as alcohol, IV drugs and inhaled drugs
- Alcohol consumption is to be strongly discouraged
- Seizure disorders not controlled with medication
- Significant cardiovascular dysfunction within the past 12 months
- Chronic pulmonary disease with documented pulmonary hypertension
- Immunologically mediated disease [e.g., inflammatory bowel disease (Crohn's disease, ulcerative colitis)], rheumatoid arthritis, idiopathic thrombocytopenia purpura, systemic lupus erythematosis, autoimmune hemolytic anemia, scleroderma, severe psoriasis, clinical cryoglobulinemia with vasculitis
Any medical condition requiring, or likely to require, chronic systemic administration of steroids during the course of the study
Evidence of an active or suspected cancer or a history of malignancy where the risk of reoccurrence is ≥ 20% within two years