PIRLONG-PD Safety and Efficacy of Piribedil in Parkinson's Disease During Long Term Therapy (PIR-008/K)

Desitin

Status: Completed

Conditions: Parkinson's Disease

Treatments: Drug: piribedil (Clarium)

Study type: Observational

Funder types: Industry

Identifiers

NCT01519856

PIR-008/K

Details and patient eligibility

About

Non-Ergot Dopamine agonists are meanwhile the drugs of first-choice in the treatment of Parkinson's disease. The receptor profile of the non-ergot dopamine-agonist piribedil is unique. In addition to agonistic effects on dopaminergic D2- and D3-receptors piribedil has adrenergic alpha-2A- and alpha-2C-receptors antagonisic properties. There is evidence from the literature that the antagonistic properties of piribedil are correlated with an improvement of cognitive function and vigilance parameters in parkinson's disease. The aim of the present non-interventional study is to investigate the safety and efficacy of piribedil during long-term therapy of patients with M. Parkinson under consideration of cognitive functions and quality of life.

Enrollment: 908 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• newly diagnosed or advanced idiopathic Parkinson's disease
• male and female patients over 18 years of age
• indication for treatment with piribedil according to Summary of Product Characteristics (SmPC)

Exclusion criteria

• in line with piribedil SmPC
• in particular hypersensitivity to piribedil or to any of the excipients and pregnancy and lactation as stated in the SmPC

Trial design

908 participants in 1 patient group

tablet

Treatment:

Drug: piribedil (Clarium)