Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

Ian J. Neeland, MD

Status: Not yet enrolling

Conditions: Food Acceptance; Obesity & Overweight; Dietary Change

Treatments: Dietary Supplement: Pistachios; Procedure: Dual-energy X-ray absorptiometry (DEXA) scans

Study type: Interventional

Funder types: Other

Identifiers

NCT07244445

STUDY20250409

Details and patient eligibility

About

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Enrollment: 108 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals with a BMI ≥30 kg/m2 who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment

Exclusion criteria

• No use or contraindication to use of a GLP-1 RA
• Known allergy to nuts
• Pregnant or breastfeeding
• Incarcerated

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

108 participants in 2 patient groups

Pistachio Group

Experimental group

Description:

Participants in this group will eat 2 ounces, or 53 grams of dry-roasted, unsalted pistachios each day along with their regular diet.

Treatment:

Procedure: Dual-energy X-ray absorptiometry (DEXA) scans

Dietary Supplement: Pistachios

No Pistachio Group

Active Comparator group

Description:

Participants in this group will continue eating regular diet without pistachios.

Treatment:

Procedure: Dual-energy X-ray absorptiometry (DEXA) scans