Pitch Perception and Memory: Deficits and Training (Pitch_Train)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Cochlear Implants

Treatments: Behavioral: visuo-spatial training protocol; Behavioral: EEG/MEG/MRI recordings.; Behavioral: Listening tests. Pitch training protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT03707691

2018-A02670-55 (Other Identifier)

69HCL18_0632

Details and patient eligibility

About

Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

Enrollment: 960 estimated patients

Sex: All

Ages: 5 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For adult participants:

• Aged between 18 and 90
• Absence of neurological and psychiatric disorders
• No major cognitive deficit, ability to understand and apply study instructions
• Motivation to participate efficiently in the study
• Written informed consent to participant in the study
• Affiliated to social security
• Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility

For underage participants:

• Subject aged 5 years and over
• Informed consent of parents or guardians for the participation of the child being studied
• No neurological or psychiatric history
• Without major cognitive impairment and ability to understand and apply setpoint.
• Subject affiliated to a social security scheme
• Motivation to participate effectively in the project

Exclusion criteria

For adult participants:

• Age below 18 or above 90
• Pregnant or breast-feeding woman

For underage participants:

• Pregnant or nursing minors

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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960 participants in 3 patient groups

Cochlear implant users

Experimental group

Description:

In both arms a pitch training protocol and a visuo-spatial training protocol are applied.

Treatment:

Behavioral: Listening tests. Pitch training protocol

Behavioral: EEG/MEG/MRI recordings.

Behavioral: visuo-spatial training protocol

Participants with Congenital Amusia

Experimental group

Description:

In both arms a pitch training protocol and a visuo-spatial training protocol are applied.

Treatment:

Behavioral: Listening tests. Pitch training protocol

Behavioral: EEG/MEG/MRI recordings.

Behavioral: visuo-spatial training protocol

Control Participants

Experimental group

Treatment:

Behavioral: Listening tests. Pitch training protocol

Behavioral: EEG/MEG/MRI recordings.

Behavioral: visuo-spatial training protocol