Pituitary Function and Spontaneous Intracranial Hypotension

Cedars-Sinai Medical Center

Status: Suspended

Conditions: Spontaneous Intracranial Hypotension; Hyperprolactinemia

Treatments: Other: Pituitary panel will be drawn pre-op and post-op for all patients.

Study type: Observational

Funder types: Other

Identifiers

NCT02603549

Pro39357

Details and patient eligibility

About

Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female patients
• Age 18 years and older
• Diagnosis of SIH:
• LP
• Brain MRI (SEEPS)

Exclusion criteria

• Pregnant and post-partum females
• Nursing mothers
• Patients with potential hyperprolactinemia due to:
• Hypothyroidism,
• Chronic renal disorder
• Liver disease (including cirrhosis)
• Primary or secondary amenorrhea
• Polycystic Ovary Syndrome
• Seizure disorder
• Illicit drug use

Trial design

100 participants in 1 patient group

Surgery or Blood Patch

Treatment:

Other: Pituitary panel will be drawn pre-op and post-op for all patients.