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Fatigue is a central symptom of obesity: it significantly impacts daily functioning, psychological well-being, compliance with physical therapy, and quality of life. However, the full understanding of the origin and treatment of fatigue in obesity is still a matter of debate, requiring further research, especially from new perspectives. From a neuroscientific perspective, fatigue is more than the subjective perception of tiredness resulting from mental or physical exertion or illness. It results in the complex interaction between (bottom-up) sensory input coming from the periphery, and motivational and psychological input, which is related to top-down cognition. In this framework, placebos may affect the output of the top-down cognitive processing by altering the individual evaluation of the ongoing peripheral performance. Indeed, evidence from both healthy conditions and clinical contexts suggests that fatigue can be modulated. The after-effect of such a modulation can be observed not only at a behavioural level, in terms of physical endurance, but also a psychological (i.e., decreased of perceived fatigue) and neurophysiological (changes in brain activity, especially in the fatigue-related components as the RP) levels.
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Inclusion criteria
• Right-handed diagnosis of obesity (the level of body mass index - BMI - higher or equal to 30).
Exclusion criteria
• concurrent neurological, neurodevelopmental (e.g., autism), motor, somatosensory and/or psychiatric disorders
80 participants in 2 patient groups
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Central trial contact
Federica Scarpina, PhD; Luca Grappiolo
Data sourced from clinicaltrials.gov
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