Placebo Effects on Blood Pressure Induced by Expectancy Manipulation

Ludwig Maximilian University of Munich

Status: Completed

Conditions: Blood Pressure

Treatments: Drug: Histaminum hydrochloricum globuli; Drug: Placebo globuli

Study type: Interventional

Funder types: Other

Identifiers

NCT00937196

KM-DZ-06

Details and patient eligibility

About

The objective of the present study was to examine the effects of a single placebo intervention on blood pressure and to investigate autonomic and psychological mediating mechanisms.

Enrollment: 45 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• informed consent

Exclusion criteria

• not meeting inclusion criteria
• hypotension or hypertension
• treated or untreated hypertension or hypotension
• Severe systemic disorders (tumors, tbc, diabetes, asthma etc)
• diseases that influence the cardiovascular or gastrointestinal system
• intake of drugs affecting blood pressure and/or autonomic nervous system
• pregnancy and lactation phase
• body mass index >= 32
• cardiovascular risk factors (diabetes, smoking)
• drug or alcohol abuse
• insufficient compliance
• participation in another trial within the last three months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

45 participants in 3 patient groups

Histaminum hydrochloricum globuli

Active Comparator group

Description:

To allow double-blind administration of the placebo pills going along with verbal suggestions of a blood-pressure-lowering effect

Treatment:

Drug: Histaminum hydrochloricum globuli

Placebo globuli

Experimental group

Treatment:

Drug: Placebo globuli

No treatment

No Intervention group