Placental Pathology and Inflammatory Factor Analysis of OAPS

Peking University

Status: Unknown

Conditions: Antiphospholipid Syndrome in Pregnancy

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05378516

yjjbear2022

Details and patient eligibility

About

This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.

Full description

1. To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group
2. consent to join this study and finish the informed consents

Exclusion criteria

pregnant women with other autoimmune diseases

Trial design

40 participants in 1 patient group

obstetric antiphospholipid syndrome

Description:

obstetric antiphospholipid syndrome 20 cases and normal pregnant women 20 cases

Treatment:

Other: no intervention