PLAIAR-Trial: Platelets in Inflammation and Resolution

University Hospital Muenster

Status: Unknown

Conditions: ARDS; Platelet Abnormality

Treatments: Diagnostic Test: Bronchoscopy, blood sampling; testing.

Study type: Observational

Funder types: Other

Identifiers

NCT05098106

12-Anit-20

Details and patient eligibility

About

Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.

Enrollment: 72 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Routine bronchoscopy
• Patient in perioperative setting
• Age >=18 years
• Consent

Exclusion criteria

• Active or recent (in past 7 days) bleeding in upper airways
• Recent traumatic injury of the lung associated with (micro-)hemorrhage
• Blood aspiration
• Pregnancy
• Age<18 years
• Acute kidney injury / Chronic kidney failure / Dialysis
• Transplantation
• HIV
• Hematologic diseases
• Immunosuppression
• Anti-Platelet-Therapy

Trial design

72 participants in 2 patient groups

Pneumonia patients with ARDS

Description:

Patients in the perioperative/intensive care setting with pneumonia-induced ARDS requiring bronchoscopy.

Treatment:

Diagnostic Test: Bronchoscopy, blood sampling; testing.

Ventilated patients without ARDS

Description:

Patients without ARDS on mechanical ventilation.

Treatment:

Diagnostic Test: Bronchoscopy, blood sampling; testing.